Dirk Bredenbröker Selected Research

Roflumilast

1/2014	Roflumilast and dyspnea in patients with moderate to very severe chronic obstructive pulmonary disease: a pooled analysis of four clinical trials.
9/2013	Cardiovascular safety in patients receiving roflumilast for the treatment of COPD.
5/2013	Efficacy of roflumilast in the COPD frequent exacerbator phenotype.
5/2012	Physiological effects of roflumilast at rest and during exercise in COPD.
11/2011	Roflumilast in Asian patients with COPD: A randomized placebo-controlled trial.
10/2011	Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects.
1/2011	Reduction of exacerbations by the PDE4 inhibitor roflumilast--the importance of defining different subsets of patients with COPD.
12/2007	Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD.
5/2006	Efficacy and safety of roflumilast in the treatment of asthma.
8/2005	Roflumilast--an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial.

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Dirk Bredenbröker Research Topics

Disease

9	Chronic Obstructive Pulmonary Disease (COPD) 01/2014 - 08/2005
3	Asthma (Bronchial Asthma) 10/2011 - 08/2005
2	Chronic Bronchitis 01/2014 - 01/2011
2	Inflammation (Inflammations) 10/2011 - 05/2006
1	Dyspnea (Shortness of Breath) 01/2014
1	Myocardial Infarction 09/2013
1	Stroke (Strokes) 09/2013
1	Respiratory Hypersensitivity 10/2011
1	Cough 01/2011
1	Emphysema 01/2011
1	Necrosis 12/2007
1	Lung Diseases (Lung Disease) 08/2005

Drug/Important Bio-Agent (IBA)

11	RoflumilastIBA 01/2014 - 08/2005
5	Phosphodiesterase 4 InhibitorsIBA 09/2013 - 05/2006
3	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 01/2014 - 08/2005
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2014 - 05/2006
2	AllergensIBA 10/2011 - 08/2005
1	Muscarinic AntagonistsIBA 01/2014
1	omega-Chloroacetophenone (Mace)IBA 09/2013
1	GoldIBA 05/2013
1	Pharmaceutical PreparationsIBA 05/2013
1	Leukocyte Elastase (Neutrophil Elastase)IBA 12/2007
1	Interleukin-8 (Interleukin 8)IBA 12/2007
1	Eosinophil Cationic ProteinIBA 12/2007
1	Bronchodilator Agents (Bronchodilators)IBA 12/2007

Therapy/Procedure

2	Therapeutics 09/2013 - 01/2011